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These conditions digestive conditions, such as Crohns disease and ulcerative colitis autoimmune conditions, such as celiac disease and type 1 diabetes genetic conditions, such as inherited intrinsic factor deficiency and inherited transcobalamin deficiency chronic pancreatic disease pernicious anemia vitiligo Other factors that may lead to a vitamin B12 deficiency can include drinking excessive amounts of alcohol or using certain drugs, such as some heartburn medicines and metformin

Larsen PJ, Tang-Christensen M, Jessop DS

It wont override a chronically high-calorie diet, but it will make eating the right amount significantly easier

Kelly FJ, Fussell JC (2019) Metabolomics as a tool to unravel the oxidative stress-induced toxicity of ambient air pollutants